Myosin X is a downstream effector of PI(3)K during phagocytosis

@article{Cox2002MyosinXI,
  title={Myosin X is a downstream effector of PI(3)K during phagocytosis},
  author={Dianne Cox and Jonathan S. Berg and Michael Cammer and John O. Chinegwundoh and Benjamin M. Dale and Richard E. Cheney and Steven M. Greenberg},
  journal={Nature Cell Biology},
  year={2002},
  volume={4},
  pages={469-477}
}
Phagocytosis is a phosphatidylinositol-3-OH-kinase (PI(3)K)-dependent process in macrophages. We identified Myo10 (Myosin-X), an unconventional myosin with pleckstrin homology (PH) domains, as a potential downstream target of PI(3)K. Myo10 was recruited to phagocytic cups in a wortmannin-sensitive manner. Expression of a truncation construct of Myo10 (Myo10 tail) in a macrophage cell line or cytosolic loading of anti-Myo10 antibodies in bovine alveolar macrophages inhibited phagocytosis. In… 

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Myosin X.

  • H. Tokuo
  • Biology
    Advances in experimental medicine and biology
  • 2020
This chapter addresses the structure of the Myo10 gene; the molecular structure of Myosin X protein with its multiple domains; the regulation of actin structures induced in cells by Myo 10; the expression and function of Myo12 in vitro and in vivo; and the role of MyO10 in cancer.

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