• Corpus ID: 12877248

Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin.

@article{Berg2000MyosinXAN,
  title={Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin.},
  author={Jonathan S. Berg and Bruce H. Derfler and C M Pennisi and David P. Corey and Richard E. Cheney},
  journal={Journal of cell science},
  year={2000},
  volume={113 Pt 19},
  pages={
          3439-51
        }
}
Myosin-X is the founding member of a novel class of unconventional myosins characterized by a tail domain containing multiple pleckstrin homology domains. We report here the full-length cDNA sequences of human and bovine myosin-X as well as the first characterization of this protein's distribution and biochemical properties. The 235 kDa myosin-X contains a head domain with <45% protein sequence identity to other myosins, three IQ motifs, and a predicted stalk of coiled coil. Like several other… 

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