Myosin-Va regulates exocytosis through the submicromolar Ca2+-dependent binding of syntaxin-1A.

@article{Watanabe2005MyosinVaRE,
  title={Myosin-Va regulates exocytosis through the submicromolar Ca2+-dependent binding of syntaxin-1A.},
  author={Michitoshi Watanabe and Kazushige Nomura and Akihiro Ohyama and Ryoki Ishikawa and Yoshiaki Komiya and Kohei Hosaka and Emiko Yamauchi and Hisaaki Taniguchi and Nobuyuki Sasakawa and Konosuke Kumakura and Tatsuo Ushiki and Osamu Sato and Mitsuo Ikebe and Michihiro Igarashi},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 10},
  pages={
          4519-30
        }
}
Myosin-Va is an actin-based processive motor that conveys intracellular cargoes. Synaptic vesicles are one of the most important cargoes for myosin-Va, but the role of mammalian myosin-Va in secretion is less clear than for its yeast homologue, Myo2p. In the current studies, we show that myosin-Va on synaptic vesicles interacts with syntaxin-1A, a t-SNARE involved in exocytosis, at or above 0.3 microM Ca2+. Interference with formation of the syntaxin-1A-myosin-Va complex reduces the exocytotic… CONTINUE READING

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