Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons.

@article{Lalli2003MyosinVA,
  title={Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons.},
  author={Giovanna Lalli and Stephen Gschmeissner and Giampietro Schiavo},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 22},
  pages={4639-50}
}
Using a novel assay based on the sorting and transport of a fluorescent fragment of tetanus toxin, we have investigated the cytoskeletal and motor requirements of axonal retrograde transport in living mammalian motor neurons. This essential process ensures the movement of neurotrophins and organelles from the periphery to the cell body and is crucial for neuronal survival. Unlike what is observed in sympathetic neurons, fast retrograde transport in motor neurons requires not only intact… CONTINUE READING

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