Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis.

@article{Buss2001MyosinVI,
  title={Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis.},
  author={Folma Buss and Susan D. Arden and Margaret Lindsay and J Paul Luzio and John Kendrick-Jones},
  journal={The EMBO journal},
  year={2001},
  volume={20 14},
  pages={3676-84}
}
Myosin VI is involved in membrane traffic and dynamics and is the only myosin known to move towards the minus end of actin filaments. Splice variants of myosin VI with a large insert in the tail domain were specifically expressed in polarized cells containing microvilli. In these polarized cells, endogenous myosin VI containing the large insert was concentrated at the apical domain co-localizing with clathrin- coated pits/vesicles. Using full-length myosin VI and deletion mutants tagged with… CONTINUE READING

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