Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton.

@article{Morris2002MyosinVB,
  title={Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton.},
  author={Shelli M. Morris and Susan D. Arden and Rhys C. Roberts and John Kendrick-Jones and Jonathan A Cooper and J Paul Luzio and Folma Buss},
  journal={Traffic},
  year={2002},
  volume={3 5},
  pages={331-41}
}
Myosin VI, an actin-based motor protein, and Disabled 2 (Dab2), a molecule involved in endocytosis and cell signalling, have been found to bind together using yeast and mammalian two-hybrid screens. In polarised epithelial cells, myosin VI is known to be associated with apical clathrin-coated vesicles and is believed to move them towards the minus end of actin filaments, away from the plasma membrane and into the cell. Dab2 belongs to a group of signal transduction proteins that bind in vitro… CONTINUE READING
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