Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane

@inproceedings{Bond2011MyosinVA,
  title={Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane},
  author={Lisa M. Bond and Andrew A Peden and John Kendrick-Jones and James R Sellers and Folma Buss},
  booktitle={Molecular biology of the cell},
  year={2011}
}
During constitutive secretion, proteins synthesized at the endoplasmic reticulum (ER) are transported to the Golgi complex for processing and then to the plasma membrane for incorporation or extracellular release. This study uses a unique live-cell constitutive secretion assay to establish roles for the molecular motor myosin VI and its binding partner optineurin in discrete stages of secretion. Small interfering RNA-based knockdown of myosin VI causes an ER-to-Golgi transport delay, suggesting… CONTINUE READING

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