Myosin IXb is a single-headed minus-end-directed processive motor

@article{Inoue2002MyosinII,
  title={Myosin IXb is a single-headed minus-end-directed processive motor},
  author={Akira Inoue and Junya Saito and Reiko Ikebe and Mitsuo Ikebe},
  journal={Nature Cell Biology},
  year={2002},
  volume={4},
  pages={302-306}
}
Myosin is an actin-based molecular motor that constitutes a diverse superfamily. In contrast to conventional myosin, which binds to actin for only a short time during cross-bridge cycling, recent studies have demonstrated that class V myosin moves along actin filaments for a long distance without dissociating. This would make it suitable for supporting cargo movement in cells. Because myosin V has a two-headed structure with an expanded neck domain, it has been postulated to 'walk' along the 36… Expand
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  • P. Xie
  • Chemistry, Medicine
  • Biophysical chemistry
  • 2010
TLDR
A Brownian ratchet model is proposed to describe this processive movement of myosin-IX, which results from its high binding affinity for actin in ATP state due to the presence of unique loop 2 insertion or N-terminal extension. Expand
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A Unique ATP Hydrolysis Mechanism of Single-headed Processive Myosin, Myosin IX*
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