Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes.

@article{Chung2010MyosinIP,
  title={Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes.},
  author={Le Thi Kim Chung and Toshio Hosaka and Nagakatsu Harada and Bayasgalan Jambaldorj and Keiko Fukunaga and Yuka Nishiwaki and Kiyoshi Teshigawara and Tohru Sakai and Yutaka Nakaya and Makoto Funaki},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={391 1},
  pages={995-9}
}
In adipocytes and myocytes, insulin stimulation translocates glucose transporter 4 (Glut4) storage vesicles (GSVs) from their intracellular storage sites to the plasma membrane (PM) where they dock with the PM. Then, Glut4 is inserted into the PM and initiates glucose uptake into these cells. Previous studies using chemical inhibitors demonstrated that myosin II participates in fusion of GSVs and the PM and increase in the intrinsic activity of Glut4. In this study, the effect of myosin IIA on… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…