Myosin IIA deficient cells migrate efficiently despite reduced traction forces at cell periphery

@inproceedings{Jorrisch2013MyosinID,
  title={Myosin IIA deficient cells migrate efficiently despite reduced traction forces at cell periphery},
  author={Melissa H. Jorrisch and Wenting Shih and Soichiro Yamada},
  booktitle={Biology open},
  year={2013}
}
Cell motility is a cornerstone of embryogenesis, tissue remodeling and repair, and cancer cell invasion. It is generally thought that migrating cells grab and exert traction force onto the extracellular matrix in order to pull the cell body forward. While previous studies have shown that myosin II deficient cells migrate efficiently, whether these cells exert traction forces during cell migration in the absence of the major contractile machinery is currently unknown. Using an array of micron… CONTINUE READING
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