Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.

@article{Yamamoto2009MyosinIR,
  title={Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.},
  author={Norio Yamamoto and Takayuki Okano and Xuefei Ma and Robert S Adelstein and Matthew William Kelley},
  journal={Development},
  year={2009},
  volume={136 12},
  pages={1977-86}
}
The sensory epithelium of the mammalian cochlea comprises mechanosensory hair cells that are arranged into four ordered rows extending along the length of the cochlear spiral. The factors that regulate the alignment of these rows are unknown. Results presented here demonstrate that cellular patterning within the cochlea, including the formation of ordered rows of hair cells, arises through morphological remodeling that is consistent with the mediolateral component of convergent extension. Non… CONTINUE READING