Myosin II activity is required for severing-induced axon retraction in vitro.

@article{Gallo2004MyosinIA,
  title={Myosin II activity is required for severing-induced axon retraction in vitro.},
  author={Gianluca Gallo},
  journal={Experimental neurology},
  year={2004},
  volume={189 1},
  pages={112-21}
}
Understanding the mechanistic basis of the response of neurons to injury is directly relevant to the development of effective therapeutic approaches aimed at the amelioration of nervous system damage. Axons retract in response to severing. We investigated the mechanism of axon retraction in response to severing in vitro, testing the hypothesis that actomyosin contractility drives severing-induced axon retraction. Axon retraction commenced within 5 min following severing and correlated with… CONTINUE READING

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