Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus.

@article{Fusi1998MyorelaxantAO,
  title={Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus.},
  author={Fabio Fusi and Massimo Valoti and Georgi V. Petkov and Kiril K. Boev and Gian Pietro Sgaragli},
  journal={European journal of pharmacology},
  year={1998},
  volume={360 1},
  pages={
          43-50
        }
}
View on PubMed
doi.org
14 Citations
Background Citations
2

14 Citations

Citation Type

Citation Type

2,5-Di-t-butyl-1,4-benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta.
3,5-di-t-butylcatechol (DTCAT) as an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).
3,5-di-t-butyl-4-hydroxyanisole (DTBHA) activation of rat skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase.
On the mechanisms of the antispasmodic action of some hindered phenols in rat aorta rings.
Negative chronotropism, positive inotropism and lusitropism of 3,5‐di‐t‐butyl‐4‐hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak
The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells
TLDR
The lack of effect in INS-1 cells suggests a potential selectivity of norbormide for smooth muscle KATP channels, a role of ATP-sensitive potassium (KATP) channels in norBormide-induced vasoconstriction.
Effect of Butylated Hydroxyanisole and Some of Its Derivatives on Human Neutrophil Oxidative Burst: Chemiluminescence Evaluation
TLDR
The ability of butylated hydroxyanisole (BHA) and some phenolic, aliphatic and aromatic BHA derivatives to reduce the human PMN oxidative burst evoked by particulate (Candida albicans and zymosan) or soluble stimulants (fMLP and phorbol myristate acetate) was investigated using luminol-amplified chemiluminescence.
Control of the phasic and tonic contractions of guinea pig stomach by a ryanodine-sensitive Ca2+ store.
Effects of some sterically hindered phenols on whole‐cell Ca2+ current of guinea‐pig gastric fundus smooth muscle cells
TLDR
The inhibition of ICa(L) by BHA and DTBHA is qualitatively similar to that of a Ca2+ channel blocker and is characterized by the stabilizing effect of the inactivated state of the channel.
Effects of quercetin and rutin on vascular preparations
TLDR
The mechanical and electrophysiological properties of quercetin and its rutoside, rutin, are investigated in an attempt to clarify how Ca2+ channel activation might be related to the myorelaxing activity.
...
1
2
...

References

SHOWING 1-10 OF 36 REFERENCES
Cyclopiazonic acid-induced changes in contractile activity of smooth muscle strips isolated from cat and guinea-pig stomach.
4-Aminopyridine-induced changes in the electrical and contractile activities of the gastric smooth muscle.
TLDR
The present data suggest that 4-AP exerts its effects via an increase in neurotransmitter release (low concentrations) and/or directly on the smooth muscle cell membrane (high concentrations).
Activation of distinct cAMP- and cGMP-dependent pathways by relaxant agents in isolated gastric muscle cells.
TLDR
The mechanism of action of vasoactive intestinal peptide was examined in isolated gastric and taenia coli muscle cells and compared with that of nitric oxide, sodium nitroprusside, and isoproterenol to conclude that cAK and cGK can be activated separately and mediate relaxation independently.
Ryanodine and the adrenergic, purinergic stimulation in the rat vas deferens smooth muscle: functional and radioligand binding studies.
TLDR
There was a lack of uniformity in the effect of ryanodine and nifedipine against alpha adrenoceptor stimulation and purinoceptor stimulation indicating a difference in the stimulation-contraction coupling process between these two modes of stimulation.
The Role of a Ryanodine-Sensitive Ca2+-Store in the Regulation of Smooth Muscle Tone of the Cat Gastric Fundus
TLDR
Evidence is provided for the role of Ca 2+ release from a SR ryanodine-sensitive Ca2+ store in the maintenance of the muscle tone of the cat gastric fundus.
Cyclic GMP-induced activation of potassium currents by sarcoplasmic reticulum Ca2+ pump-dependent mechanism.
TLDR
The authors' data suggest that, in gastric fundus smooth muscles, NO-liberating substances and cGMP analogues contribute to the activation of a Ca2+ -release mechanism from the cell bulk, i.e. the myoplasm surrounding the contractile filaments, towards the plasma membrane, crossing the SR Ca2-stores.
Inhibition by some phenolic antioxidants of Ca2+ uptake and neurotransmitter release from brain synaptosomes.
Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum.
TLDR
It is found that at low ATP concentrations (0.5-2 microM) the inhibition of ATPase activity was essentially complete at a CPA concentration of 6-8 nmol/mg protein, indicating stoichiometric reaction of CPA with the Ca2+-ATPase, which suggests that CPA interferes with the ATP-induced conformational changes related to Ca2- transport.
Pharmacological properties of the novel non-steroidal antiinflammatory agent N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2 -one.
TLDR
E-5110 is a very potent antiinflammatory compound acting against various types of inflammation, and has a favorable therapeutic index.
Use of ryanodine for functional removal of the calcium store in smooth muscle cells of the guinea-pig.
...
1
2
3
4
...