Myoplasmic [Ca2+] determines myosin phosphorylation in agonist-stimulated swine arterial smooth muscle.

@article{Rembold1988MyoplasmicD,
  title={Myoplasmic [Ca2+] determines myosin phosphorylation in agonist-stimulated swine arterial smooth muscle.},
  author={Christopher M. Rembold and Richard A. Murphy},
  journal={Circulation research},
  year={1988},
  volume={63 3},
  pages={
          593-603
        }
}
Our objective was to test the hypotheses that 1) myoplasmic [Ca2+] is the primary determinant of crossbridge phosphorylation and that 2) phosphorylation is the primary determinant of crossbridge interactions with the thin filament in swine carotid arterial smooth muscle. We tested these hypotheses by evaluating the relation between aequorin-estimated myoplasmic [Ca2+], myosin light chain phosphorylation, shortening velocity at zero load (V0), and stress at various times after stimulation with… CONTINUE READING
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