Myonuclear domain and myosin phenotype in human soleus after bed rest with or without loading.

@article{Ohira1999MyonuclearDA,
  title={Myonuclear domain and myosin phenotype in human soleus after bed rest with or without loading.},
  author={Yoshinobu Ohira and Tomoo Yoshinaga and Makoto Ohara and Ikuya Nonaka and Toshitada Yoshioka and Katsumasa Yamashita-Goto and B. S. Shenkman and Inessa B. Kozlovskaya and Roland R. Roy and V. Reggie Edgerton},
  journal={Journal of applied physiology},
  year={1999},
  volume={87 5},
  pages={1776-85}
}
After 2 or 4 mo of bed rest (6 degrees head-down tilt) and 1 mo of ambulation, there was a tendency toward a higher percentage of fibers expressing fast myosin heavy chain (MHC) isoforms and a de novo appearance of fibers coexpressing type I+IIa+IIx and IIa+IIx MHC in human soleus fibers. After 2 and 4 mo of bed rest, the mean size of type I fibers decreased by 12 (P > 0.05) and 39%, respectively. Because myonuclear number/mm of fiber length was unchanged, myonuclear domain was smaller after… CONTINUE READING
62 Citations
33 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Neuromuscular adaptation to actual and stimulated spaceflight

  • V. R. Edgerton, R. R. Roy
  • Handbook of Physiology. Environmental Physiology…
  • 1996
2 Excerpts

Similar Papers

Loading similar papers…