Myoglobin protects the heart from inducible nitric-oxide synthase (iNOS)-mediated nitrosative stress.

@article{Goedecke2003MyoglobinPT,
  title={Myoglobin protects the heart from inducible nitric-oxide synthase (iNOS)-mediated nitrosative stress.},
  author={Axel Goedecke and Andre Molojavyi and Jacqueline Heger and Ulrich Floegel and Zhaoping Ding and Christoph Jacoby and Juergen Schrader},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 24},
  pages={21761-6}
}
The role of inducible nitric-oxide synthase (iNOS) in the pathogenesis of heart failure is still a matter of controversy. In contrast to early reports favoring a contribution of iNOS because of the negative inotropic and apoptotic potential of NO, more recent clinical and experimental data question a causative role. Here we report that transgenic mice with cardiac specific iNOS-overexpression and concomitant myoglobin-deficiency (tg-iNOS+/myo-/-) develop signs of heart failure with cardiac… CONTINUE READING