Myoglobin over-expression attenuates angiogenic response in hindlimb ischemia in mice.

@article{Yang2009MyoglobinOA,
  title={Myoglobin over-expression attenuates angiogenic response in hindlimb ischemia in mice.},
  author={Yao-guo Yang and Heng Guan and Changwei Liu and Yongjun Li},
  journal={Chinese medical journal},
  year={2009},
  volume={122 9},
  pages={1056-60}
}
BACKGROUND Myoglobin is expressed exclusively in striated skeletal muscles and has been implicated in nitric oxide scavenging. Accumulating data suggest a critical role for nitric oxide in both the endogenous and therapeutic angiogenic response to ischemia. A clear role for myoglobin in ischemic skeletal muscle is uncertain. We hypothesized that myoglobin… CONTINUE READING