Myoglobin as a model system for designing heme protein based blood substitutes.

@article{Dou2002MyoglobinAA,
  title={Myoglobin as a model system for designing heme protein based blood substitutes.},
  author={Yi Dou and David H Maillett and Raymund F Eich and John S Olson},
  journal={Biophysical chemistry},
  year={2002},
  volume={98 1-2},
  pages={127-48}
}
The ligand binding properties and resistances to denaturation of >300 different site-directed mutants of sperm whale, pig, and human myoglobin have been examined over the past 15 years. This library of recombinant proteins has been used to derive chemical mechanisms for ligand binding and to examine the factors governing holo- and apoglobin stability. We… CONTINUE READING