Myogenin is a Specific Marker for Rhabdomyosarcoma: An Immunohistochemical Study in Paraffin-Embedded Tissues

@article{Kumar2000MyogeninIA,
  title={Myogenin is a Specific Marker for Rhabdomyosarcoma: An Immunohistochemical Study in Paraffin-Embedded Tissues},
  author={S. Kumar and Elizabeth J. Perlman and Cynthia A. Harris and Mark Raffeld and Maria G. Tsokos},
  journal={Modern Pathology},
  year={2000},
  volume={13},
  pages={988-993}
}
Myogenin belongs to a group of myogenic regulatory proteins whose expression determines commitment and differentiation of primitive mesenchymal cells into skeletal muscle. The expression of myogenin has been demonstrated to be extremely specific for rhabdomyoblastic differentiation, which makes it a useful marker in the differential diagnosis of rhabdomyosarcomas (RMS) from other malignant small round cell tumors of childhood. Commercially available antibodies capable of detecting myogenin in… 
Diffuse Myogenin Expression by Immunohistochemistry is an Independent Marker of Poor Survival in Pediatric Rhabdomyosarcoma: A Tissue Microarray Study of 71 Primary Tumors Including Correlation With Molecular Phenotype
The pathologic classification of rhabdomyosarcoma (RMS) into embryonal or alveolar subtype is an important prognostic factor guiding the therapeutic protocol chosen for an individual patient.
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    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2005
TLDR
The findings indicate that, in this anatomic site, the diagnosis of rhabdomyosarcoma and in particular determination of tumor margins remain very reliant on histomorphology.
Myogenic Markers in the Evaluation of Embryonal Botryoid Rhabdomyosarcoma of the Female Genital Tract
  • W. Riedlinger, H. Kozakewich, S. Vargas
  • Medicine, Biology
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2005
TLDR
The findings indicate that, in this anatomic site, the diagnosis of rhabdomyosarcoma and in particular determination of tumor margins remain very reliant on histomorphology.
An Immunohistochemical Algorithm to Facilitate Diagnosis and Subtyping of Rhabdomyosarcoma: The Children's Oncology Group Experience
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Their differential expression in reactive myogenic lesions, variability in ARMS versus ERMS, and absence in undifferentiated sarcomas suggest new biologic questions to be explored in future studies.
PAX7 Expression in Rhabdomyosarcoma, Related Soft Tissue Tumors, and Small Round Blue Cell Neoplasms
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Investigation of the expression of PAX7, a transcriptional regulator of mammalian muscle progenitor cells implicated in the pathogenesis of rhabdomyosarcoma, finds it may be a useful diagnostic tool in the assessment of skeletal muscle differentiation in human tumors.
The Expression of WT1 in the Differentiation of Rhabdomyosarcoma from Other Pediatric Small Round Blue Cell Tumors
TLDR
A strong cytoplasmic staining favors an RMS, and a strong nuclear staining is suggestive of a Wilms' tumor, suggesting a role for WT1 in the pathogenesis of rhabdomyosarcomas is raised.
Evaluation of Myogenin and MyoD1 as Immunohistochemical Markers of Canine Rhabdomyosarcoma
TLDR
It is demonstrated that MyoD1 and myogenin should be included with desmin as part of a diagnostic IHC panel for canine RMS, and utilization of these antibodies to improve the accuracy of canine R MS diagnosis will ultimately allow for better characterization of the biological behavior and clinical outcomes of this disease.
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TLDR
It is demonstrated that employing molecular diagnostics has an impact on staging, therapy monitoring and recognition of malignant cells at the tumor resection margins.
Immunohistochemistry of Small Blue Round Cell Tumors
TLDR
In summary, there now exists a panel of antibodies defining immunohistochemical markers of individual SBRCTs that can identify rhabdomyosarcoma, PNET/Ewings sarcomA, neuroblastoma, and DSRCT with high sensitivity and specificity.
Pediatric Benign Tumors With a Skeletal Muscle Component: Myogenin Expression, Diagnostic Pitfalls, and New Molecular Insights
  • Lara Berklite, J. Ozolek, R. Alaggio
  • Medicine
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2021
TLDR
Myogenin and MyoD1 may be variably expressed in benign lesions with skeletal muscle differentiation and the knowledge of the relationship between rhabdomyoma and RMS is expanded by identifying a shared molecular alteration in ZEB2.
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