Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases

@article{Moresi2010MyogeninAC,
  title={Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases},
  author={Viviana Moresi and Andrew H. Williams and Eric Meadows and Jesse M. Flynn and Matthew J Potthoff and John R. McAnally and John M Shelton and Johannes Backs and William H. Klein and J. A. Richardson and Rhonda Bassel-Duby and Eric N Olson},
  journal={Cell},
  year={2010},
  volume={143},
  pages={35-45}
}
Maintenance of skeletal muscle structure and function requires innervation by motor neurons, such that denervation causes muscle atrophy. We show that myogenin, an essential regulator of muscle development, controls neurogenic atrophy. Myogenin is upregulated in skeletal muscle following denervation and regulates expression of the E3 ubiquitin ligases MuRF1 and atrogin-1, which promote muscle proteolysis and atrophy. Deletion of myogenin from adult mice diminishes expression of MuRF1 and… CONTINUE READING
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