Myogenic responses of mouse isolated perfused renal afferent arterioles: effects of salt intake and reduced renal mass.

@article{Lai2010MyogenicRO,
  title={Myogenic responses of mouse isolated perfused renal afferent arterioles: effects of salt intake and reduced renal mass.},
  author={En Yin Lai and Maristela Lika Onozato and Glenn Solis and Shakil Aslam and William J. Welch and Christopher Stuart Wilcox},
  journal={Hypertension},
  year={2010},
  volume={55 4},
  pages={983-9}
}
Because defects in renal autoregulation may contribute to renal barotrauma in chronic kidney disease, we tested the hypothesis that the myogenic response is diminished by reduced renal mass. Kidneys from 5/6 nephrectomized mice had only a minor increase in the glomerular sclerosis index. The telemetric mean arterial pressure (108+/-10 mm Hg) was unaffected after 3 months of high-salt intake (6% salt in chow) or reduced renal mass. Afferent arterioles from 5/6 nephrectomized mice and sham… CONTINUE READING

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