Myogenic constriction and dilation of isolated lymphatic vessels.

  title={Myogenic constriction and dilation of isolated lymphatic vessels.},
  author={Michael J Davis and Ann McGrath Davis and Christine W Ku and Anatoliy A. Gashev},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={296 2},
We tested the hypothesis that lymphatics would exhibit myogenic constrictions and dilations to intraluminal pressure changes. Collecting lymphatic vessels were isolated from rat mesentery, cannulated, and pressurized for in vitro study. The lymphatic diameter responses to controlled intraluminal pressure steps of different magnitudes were tested in the absence and presence of the inflammatory mediator substance P, which is known to enhance lymphatic contractility. Myogenic constriction, defined… CONTINUE READING