Myogenic Induction of Aligned Mesenchymal Stem Cell Sheets by Culture on Thermally Responsive Electrospun Nanofibers.

@article{Dang2007MyogenicIO,
  title={Myogenic Induction of Aligned Mesenchymal Stem Cell Sheets by Culture on Thermally Responsive Electrospun Nanofibers.},
  author={Jiyoung M Dang and Kam W. Leong},
  journal={Advanced materials},
  year={2007},
  volume={19 19},
  pages={
          2775-2779
        }
}
Exploration of artificial, nanometer-scale features to mimic natural matrices has revealed a powerful influence of nano-topography over cellular behavior. In this study, aligned nanofibers composed of thermally responsive hydroxybutyl chitosan were electrospun to create a robust scaffold for the production of aligned cell sheets. With a median fiber diameter of 436 nm, fiber alignment created repetitively spaced nanometer-scale topographical features on the scaffold surface. When cultured on… CONTINUE READING

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