Myofilament calcium sensitivity is decreased in skinned cardiac fibres of endotoxin-treated rabbits.

@article{Tavernier1998MyofilamentCS,
  title={Myofilament calcium sensitivity is decreased in skinned cardiac fibres of endotoxin-treated rabbits.},
  author={Bruno Tavernier and D Garrigue and C Boulle and Beno{\^i}t Vallet and Pascal Adnet},
  journal={Cardiovascular research},
  year={1998},
  volume={38 2},
  pages={472-9}
}
OBJECTIVE The aim was to determine whether myofilament Ca2+ sensitivity is altered in skinned cardiac fibres from endotoxin-treated rabbits. METHODS Endotoxin was injected i.v. in conscious New-Zealand White rabbits at a dose of 0.5 mg/kg (groups I, II, and III) or 1 mg/kg (group IV). A fifth group was used as control. Hearts were excised 4 h (groups I and IV), 24 h (group II), or 5 days (Group III) after injection. Skinned fibres were obtained with chemical (EGTA + Brij 58) treatment of… CONTINUE READING