Myofilament calcium sensitivity in skinned rat cardiac trabeculae: role of interfilament spacing.

@article{Konhilas2002MyofilamentCS,
  title={Myofilament calcium sensitivity in skinned rat cardiac trabeculae: role of interfilament spacing.},
  author={John P. Konhilas and T. Irving and Pieter P. de Tombe},
  journal={Circulation research},
  year={2002},
  volume={90 1},
  pages={59-65}
}
The increase in myofilament Ca(2+) responsiveness on an increase in sarcomere length (SL) is, in part, the cellular basis for Frank-Starling's law of the heart. It has been suggested that a decrease in myofilament lattice spacing (LS) in response to an increase in SL underlies this phenomenon. This hypothesis is supported by previous studies in which reduced muscle width induced by osmotic compression was associated with an increase in Ca(2+) sensitivity, mimicking those changes observed with… CONTINUE READING

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References

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Showing 1-10 of 33 references

Osmotic compression and myofilament lattice spacing in rat cardiac trabeculae

  • JP Konhilas, TC Irving, SH Smith, PP. de Tombe
  • Biophys J. 2001;80:1059
  • 2001

Is the regulation by stretch of the Ca2 sensitivity of myofilaments in cardiomyocytes only controlled by the interfilament lattice spacing

  • A Lacampagne, G Cantos, G. Vassort
  • J Muscle Res Cell Motil
  • 2000

FIT2DV9.129 Reference Manual Version 3.1. Grenoble, France: European Synchrotron Radiation Facility

  • AP Hammersley
  • 1998

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