Myofibrosarcoma of the head and neck in children.

  title={Myofibrosarcoma of the head and neck in children.},
  author={Donna Marie Smith and Hazem H Mahmoud and Jesse J. Jenkins and B Vishal Rao and Kenneth P. Hopkins and David M. Parham},
  journal={Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association},
  volume={15 3},
We have identified a distinctive malignant soft tissue neoplasm that occurred in the head and neck region of six children. Histologically, these neoplasms presented an array of features ranging from low-grade spindle cell to high-grade fibrohistiocytic histologies and often had myoid characteristics. Ultrastructural and immunohistochemical studies indicated that they contained neoplastic myofibroblasts that were variably positive for vimentin (4 positive/4 tested), alpha-smooth muscle actin (4… CONTINUE READING