Myofibroblasts in Fibrotic Kidneys.

  title={Myofibroblasts in Fibrotic Kidneys.},
  author={Naoki Nakagawa and Jeremy S. Duffield},
  journal={Current pathobiology reports},
  volume={1 3}
Fibrosis of the kidney glomerulus and interstitium are characteristic features of almost all chronic kidney diseases. Fibrosis is tightly associated with destruction of capillaries, inflammation, and epithelial injury which progresses to loss of nephrons, and replacement of kidney parenchyma with scar tissue. Understanding the origins and nature of the cells known as myofibroblasts that make scar tissue is central to development of new therapeutics for kidney disease. Whereas many cell lineages… CONTINUE READING

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