Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas.

@article{Yen2002MyofibroblastsAR,
  title={Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas.},
  author={Tina W. F. Yen and Nils Petter Aardal and Mary P Bronner and David R Thorning and Christopher E. Savard and Sum Ping Lee and Richard H. Bell},
  journal={Surgery},
  year={2002},
  volume={131 2},
  pages={129-34}
}
BACKGROUND The cell type responsible for the desmoplastic reaction surrounding human pancreatic carcinoma is unknown. Hepatic stellate cells, which activate to a myofibroblast-like form, are responsible for collagen deposition in cirrhosis and around hepatocellular carcinomas. Recently, pancreatic stellate cells have been described and implicated in the fibrosis of chronic pancreatitis. We sought to determine whether these cells are responsible for the scirrhous reaction surrounding pancreatic… CONTINUE READING

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