Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair.

@article{Virag2003MyofibroblastAE,
  title={Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair.},
  author={Jitka Ismail Virag and Charles E Murry},
  journal={The American journal of pathology},
  year={2003},
  volume={163 6},
  pages={2433-40}
}
Granulation tissue formation is a critical step in infarct repair, however, the kinetics of cell replication and the molecules that regulate this process are poorly understood. In uninjured mouse hearts and at 2 days post-infarction, very little DNA synthesis (measured by incorporation of a BrdU pulse) was detected in any cell type. Four days after permanent coronary occlusion, the rates of myofibroblast (smooth muscle alpha-actin and BrdU double-positive) and endothelial cell (CD31 and BrdU… CONTINUE READING
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