Myofibrillar adaptations during cardiac hypertrophy

  title={Myofibrillar adaptations during cardiac hypertrophy},
  author={Robin L. Toffolo and C. David Ianuzzo},
  journal={Molecular and Cellular Biochemistry},
The main purpose of this study was to determine the transmural adaptive changes that occur in cell size, myofibrils, and myosin isoforms from the endocardium (ENDO) to the epicardium (EPI) of the left ventricle (LV) of the rat heart during compensatory hypertrophy. Hypertrophy was induced by supra-renal aortic constriction for periods of 2, 7, 15 and 30 days. Percent left ventricular hypertrophy averaged 63±9.7% at 30 days following constriction. A significant (p <0.05) transmural gradient in… CONTINUE READING
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