Myofibril Membranes in Relation to the Neuromuscular Weakness of Acute Monocrotophos Poisoning

@article{Venkatesh2006MyofibrilMI,
  title={Myofibril Membranes in Relation to the Neuromuscular Weakness of Acute Monocrotophos Poisoning},
  author={S. Venkatesh and Anand Zachariah and Anna Oommen},
  journal={Toxicology Mechanisms and Methods},
  year={2006},
  volume={16},
  pages={419 - 426}
}
Organophosphate poisoning is a common method of deliberate self-harm in countries where the pesticides are readily available. The severity of neuroparalysis and myopathy occurring in acute organophosphate poisoned patients is determined by the severity of poisoning and is associated with morbidity and mortality. Molecular mechanisms that underlie severe paralysis are not well delineated but are essential to know to improve treatment. In this study rats were subjected to increasing doses (0.25… 
View on Taylor & Francis
ncbi.nlm.nih.gov
2 Citations
Background Citations
1

2 Citations

Citation Type

Citation Type

Multipesticide Residue Assessment of Agricultural Soil and Water in Major Farming Areas in Benguet, Philippines
This study investigated the concentration and presence of pesticide residues in water and soil in Benguet, which is a vegetable producing region in the Philippines. Seventy-eight samples and 49 water…
Changes in Ca2+,Mg2+-ATP enzymatic activity in sarcoplasmic reticulum and contraction strengths

References

SHOWING 1-10 OF 37 REFERENCES
Muscle injury in organophosphorous poisoning and its role in the development of intermediate syndrome.
Quinidine prevents paraoxon-induced necrotizing myopathy in rats.
Acute organophosphorus anticholinesterase poisoning induces a necrotizing end-plate myopathy in rats and patients. Acetylcholine (ACh) excess leads to prolonged synaptic currents and increased influx…
Oxidative damage in intermediate syndrome of acute organophosphorous poisoning.
TLDR
In acute organophosphate poisoning, severe and prolonged acetylcholinesterase inhibition is associated with oxidative stress, detected in erythrocyte membranes, that occurs early in the course of poisoning and may contribute to the development and severity of intermediate syndrome.
The Role of Oximes in the Management of Organophosphorus Pesticide Poisoning
  • P. Eyer
  • Medicine, Biology
    Toxicological reviews
  • 2003
TLDR
In vitro studies with human erythrocyte AChE revealed marked differences in the potency and efficacy of pralidoxime, obidoximes, HI 6 and HLö 7, the latter two oximes being considered particularly effective in nerve agent poisoning.
Organophosphorus poisoning and anaesthesia
TLDR
The roles of agents that have reduced the toxicity of organophosphorus compounds in animal experiments are discussed as potential therapeutic agents and there is an urgent need for accurate information on the problems associated with exposure to organoph phosphate compounds.
Histological and histochemical study of paraoxon myopathy in the rat.
TLDR
In low-dose poisoned rats without major cholinergic symptoms or end-plate cholinesterase inhibition, necrotic fibers were also present, which indicates that not only end-plates cholinexterases inhibition but also neural or neuronal factors might be responsible for acetylcholine overflow and muscle fiber degeneration.
Organic insecticides.
TLDR
Treatment is primarily supportive and includes decontamination, protection of airways and cardiac and respiratory monitoring, and specific therapy for organophosphates and organocarbamates includes the use of anticholinergics.
[Lipids of plasmamembranes and of mitochondria in rat liver after intoxication with paraoxon (author's transl)].
TLDR
The differences in cholesterol and phospholipid content, their degree and their timing, which agrees with the timing of enzyme leakage, suggest that lipid composition of the plasma membrane may be one of the parameters which determine membrane permeability after organophosphate poisoning.
Agonist-induced myopathy at the neuromuscular junction is mediated by calcium
TLDR
The results favor the hypothesis that esterase inhibition leads to an agonist-induced myopathy, which is mediated by Ca++ and requires an intact AChR, and could be prevented by inactivating the acetylcholine receptors with alpha- bungarotoxin or by removing Ca++ from the bath with EGTA.
Interaction of organophosphorus compounds with carboxylesterases in the rat
TLDR
Findings have changed current understanding of the mechanism of interaction of CarbE with OPC and involvement of the enzymes in detoxication of OPC, suggesting an active and important role of the enzyme in metabolic conversions of O PC to their less toxic metabolites.
...
1
2
3
4
...