Myocyte proliferation in end-stage cardiac failure in humans.

@article{Kajstura1998MyocytePI,
  title={Myocyte proliferation in end-stage cardiac failure in humans.},
  author={Jan Kajstura and Annarosa Leri and Nicoletta Finato and Carla Di Loreto and Carlo Alberto Beltrami and Piero Anversa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 15},
  pages={
          8801-5
        }
}
Introduced several decades ago, the dogma persists that cardiac myocytes are terminally differentiated cells and that division of muscle cells is impossible in the adult heart. More recently, nuclear mitotic divisions in myocytes occasionally were seen, but those observations were challenged on the assumption that the rate of cell proliferation was inconsequential for actual tissue regeneration. Moreover, mitoses were never detected in normal myocardium. However, the analysis of routine… CONTINUE READING

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