Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.

@article{Anversa1990MyocyteCL,
  title={Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.},
  author={Piero Anversa and T Palackal and Edmund H. Sonnenblick and Giorgio Olivetti and Leonard G. Meggs and Joseph M. Capasso},
  journal={Circulation research},
  year={1990},
  volume={67 4},
  pages={871-85}
}
To determine the effects of age on the myocardium, the functional and structural characteristics of the heart were studied in rats at 4, 12, 20, and 29 months of age. Mean arterial pressure, left ventricular pressure and its first derivative (dP/dt), and heart rate were comparable in rat groups up to 20 months. During the interval from 20 to 29 months, elevated left ventricular end-diastolic pressure and decreased dP/dt indicated that a significant impairment of ventricular function occurred… CONTINUE READING
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