Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.

@article{Bialik1997MyocyteAD,
  title={Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.},
  author={Shani Bialik and David L. Geenen and Isaac E. Sasson and Rui Cheng and James W. Horner and Sylvia M. Evans and Edith M. Lord and Cameron J. Koch and Richard N Kitsis},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 6},
  pages={1363-72}
}
Significant numbers of myocytes die by apoptosis during myocardial infarction. The molecular mechanism of this process, however, remains largely unexplored. To facilitate a molecular genetic analysis, we have developed a model of ischemia-induced cardiac myocyte apoptosis in the mouse. Surgical occlusion of the left coronary artery results in apoptosis, as… CONTINUE READING