Myocardin-related transcription factors are required for cardiac development and function.

Abstract

Myocardin-Related Transcription Factors A and B (MRTF-A and MRTF-B) are highly homologous proteins that function as powerful coactivators of serum response factor (SRF), a ubiquitously expressed transcription factor essential for cardiac development. The SRF/MRTF complex binds to CArG boxes found in the control regions of genes that regulate cytoskeletal… (More)
DOI: 10.1016/j.ydbio.2015.09.006

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