Myocardin-related transcription factors are required for skeletal muscle development.

  title={Myocardin-related transcription factors are required for skeletal muscle development.},
  author={Bercin Kutluk Cenik and Ning Liu and Beibei Chen and Svetlana Bezprozvannaya and Eric N Olson and Rhonda Bassel-Duby},
  volume={143 15},
Myocardin-related transcription factors (MRTFs) play a central role in the regulation of actin expression and cytoskeletal dynamics. Stimuli that promote actin polymerization allow for shuttling of MRTFs to the nucleus where they activate serum response factor (SRF), a regulator of actin and other cytoskeletal protein genes. SRF is an essential regulator of skeletal muscle differentiation and numerous components of the muscle sarcomere, but the potential involvement of MRTFs in skeletal muscle… CONTINUE READING
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