Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells.

@article{Tian2015MyocardinRT,
  title={Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells.},
  author={Wenfang Tian and Chenzhi Hao and Zhiwen Fan and Xinyu Weng and Hao Qin and Xiaoyan Wu and Mingming Fang and Qi Chen and Aiguo Shen and Yong Xu},
  journal={Journal of hepatology},
  year={2015},
  volume={62 1},
  pages={
          165-74
        }
}
BACKGROUND & AIMS Activation of hepatic stellate cells (HSCs) represents a key process in liver injury and, in the absence of intervention, leads to irreversible cirrhosis contributing significantly to the mortality of patients with liver disease. A missing link in the current understanding of HSC activation is the involvement of the epigenetic machinery. We investigated the role of the myocardin related transcription factor A (MRTF-A) in HSC activation. METHODS Liver fibrosis was induced in… CONTINUE READING
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