Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production.

@article{Liu2018MyocardinrelatedTF,
  title={Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production.},
  author={L. Liu and Xiaoyan Wu and H. Xu and Liming Yu and Xinjian Zhang and Luyang Li and Jianliang Jin and Tao Zhang and Y. Xu},
  journal={Biochimica et biophysica acta. Molecular basis of disease},
  year={2018},
  volume={1864 10},
  pages={
          3109-3121
        }
}
  • L. Liu, Xiaoyan Wu, +6 authors Y. Xu
  • Published 2018
  • Medicine
  • Biochimica et biophysica acta. Molecular basis of disease
A host of pathogenic factors induce acute kidney injury (AKI) leading to insufficiencies of renal function. In the present study we evaluated the role of myocardin-related transcription factor A (MRTF-A) in the pathogenesis of AKI. We report that systemic deletion of MRTF-A or inhibition of MRTF-A activity with CCG-1423 significantly attenuated AKI in mice induced by either ischemia-reperfusion or LPS injection. Of note, MRTF-A deficiency or suppression resulted in diminished renal ROS… Expand
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