Corpus ID: 18702012

Myocardin-Related Transcription Factors : Critical Coactivators Regulating

  title={Myocardin-Related Transcription Factors : Critical Coactivators Regulating},
  author={M. Parmacek and M. Jain},
The association of transcriptional coactivators with DNA-binding proteins provides an efficient mechanism to expand and modulate genetic information encoded within the genome. Myocardin-related transcription factors (MRTFs), including myocardin, MRTF-A/MKL1/MAL, and MRTF-B/MKL2, comprise a family of related transcriptional coactivators that physically associate with the MADS box transcription factor, serum response factor, and synergistically activate transcription. MRTFs transduce cytoskeletal… Expand
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