Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury

@article{Fang2011MyocardinRelatedTF,
  title={Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury},
  author={Fei Fang and Yuyu Yang and Zhibin Yuan and Yuqi Gao and Jiliang Zhou and Qi Chen and Yong Xu},
  journal={Circulation Research},
  year={2011},
  volume={108},
  pages={797–807}
}
Rationale: Atherosclerosis proceeds through a multistep reaction that begins with endothelial injury caused by a host of stress signals, among which oxidized low-density lipoprotein (oxLDL) plays a critical role. OxLDL disrupts normal functionality of the endothelium by upregulating adhesion molecules (eg, ICAM-1) and concomitantly downregulating endothelial nitric oxide synthase (eNOS) expression. The transcriptional modulator that mediates the cellular response to oxLDL remains largely… Expand
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