Myocardial triglycerides increased by fasting. Effects of hypoxia on contractility and enzymatic release.


The effect of fasting on the mechanics of contraction was studied in the isolated perfused rat heart, in oxygenated and hypoxic conditions. Animals were subjected to 48 h of fasting, a condition which produces augmented endogenous triglycerides (TG). Normal and fasted rats were submitted to a 10-min period of hypoxia, which depressed peak tension (Tp… (More)