Myocardial survival signaling in response to stem cell transplantation.

  title={Myocardial survival signaling in response to stem cell transplantation.},
  author={Hongzhe Li and Deepak K Malhotra and Che-chung Yeh and Richard Y K Tu and Bo-qing Zhu and Noy Birger and Andrew D. Wisneski and John Cha and Joel S. Karliner and Michael J Mann},
  journal={Journal of the American College of Surgeons},
  volume={208 4},
BACKGROUND Experimental human stem cell transplantation to the heart has begun, but the mechanisms underlying benefits seen in preclinical models, both at the site of cell injection and at more distant regions, remain uncertain. We hypothesize that these benefits can be best understood first at the level of key intracellular signaling cascades in the host myocardium, which can be responsible for functional and structural preservation of the heart. STUDY DESIGN Western blot and ELISA were used… CONTINUE READING

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