Myocardial stretch induced by increased left ventricular diastolic pressure preconditions isolated perfused hearts of normotensive and spontaneously hypertensive rats

@article{Nakagawa1997MyocardialSI,
  title={Myocardial stretch induced by increased left ventricular diastolic pressure preconditions isolated perfused hearts of normotensive and spontaneously hypertensive rats},
  author={Chiaki Nakagawa and Jun Asayama and Maki Katamura and Satoaki Matoba and Natsuya Keira and Akira Kawahara and Kouki Tsuruyama and Takao Tanaka and Miyuki Kobara and Kazuko Akashi and Bon Ohta and Tomiwo Tatsumi and Masao Nakagawa},
  journal={Basic Research in Cardiology},
  year={1997},
  volume={92},
  pages={410-416}
}
Objective: The aim of our study was to determine whether myocardial stretch (non-ischemic stress) could precondition isolated perfused hearts of both normotensive Wister-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR).Methods: The perfused hearts in Langendorff mode were subjected to 30 min of global no-flow ischemia followed by 30 min of reperfusion. Left ventricular developed pressure (LVDP) and end-diastolic pressure (LVEDP) were measured. In the control group, LVEDP was set at 10… CONTINUE READING

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