Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice.

@article{Turki1996MyocardialSD,
  title={Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice.},
  author={Jamal Turki and John N. Lorenz and Stuart Alan Green and Erling T. Donnelly and Marco Rivera Jacinto and Stephen B. Liggett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 19},
  pages={
          10483-8
        }
}
A threonine to isoleucine polymorphism at amino acid 164 in the fourth transmembrane spanning domain of the beta 2-adrenergic receptor (beta 2AR) is known to occur in the human population. The functional consequences of this polymorphism to catecholamine signaling in relevant cells or to end-organ responsiveness, however, are not known. To explore potential differences between the two receptors, site-directed mutagenesis was carried out to mimic the polymorphism. Transgenic FVB/N mice were then… CONTINUE READING
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