Myocardial reperfusion injury. Role of myocardial hypoxanthine and xanthine in free radical-mediated reperfusion injury.

@article{AbdElfattah1988MyocardialRI,
  title={Myocardial reperfusion injury. Role of myocardial hypoxanthine and xanthine in free radical-mediated reperfusion injury.},
  author={Anwar S.A. Abd-Elfattah and Michael E. Jessen and Jon Lekven and Norma Doherty and Louis A. Brunsting and Andrew S. Wechsler},
  journal={Circulation},
  year={1988},
  volume={78 5 Pt 2},
  pages={
          III224-35
        }
}
The aim of this study was to differentiate myocardial reperfusion injury from that of ischemia. We assessed the role of the myocardial adenosine 5'-triphosphate (ATP) catabolites, hypoxanthine and xanthine, generated during ischemia and the early phase of reperfusion, in reperfusion injury by modulating adenosine transport and metabolism with specific metabolic inhibitors. This was followed by intracoronary infusion of exogenous hypoxanthine and xanthine. Twenty-four dogs instrumented with… CONTINUE READING

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