Myocardial regulation of transforming growth factor-beta expression by outflow tract endothelium in the early embryonic chick heart.

@article{Nakajima1994MyocardialRO,
  title={Myocardial regulation of transforming growth factor-beta expression by outflow tract endothelium in the early embryonic chick heart.},
  author={Yuji Nakajima and Edward L. Krug and Roger R. Markwald},
  journal={Developmental biology},
  year={1994},
  volume={165 2},
  pages={615-26}
}
We have demonstrated previously that the epithelial-mesenchymal transformation of cardiac endothelium in early chick heart development is induced by EDTA-soluble (ES) extracellular molecules synthesized by the myocardium of specific regions, i.e., the outflow tract (OT) and atrioventricular (AV) canal. Polyclonal antibodies (ES3) prepared against these molecules recognized two major bands, 28 and 46 kDa, in immunoblots and blocked the transformation of OT endothelial cells into mesenchyme in a… CONTINUE READING
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