Myocardial protective effects of adenosine. Infarct size reduction with pretreatment and continued receptor stimulation during ischemia.

@article{Toombs1992MyocardialPE,
  title={Myocardial protective effects of adenosine. Infarct size reduction with pretreatment and continued receptor stimulation during ischemia.},
  author={Christopher F. Toombs and Steven McGee and William E. Johnston and Jakob Vinten-Johansen},
  journal={Circulation},
  year={1992},
  volume={86 3},
  pages={986-94}
}
BACKGROUND We hypothesized that 1) endogenous adenosine released during ischemia conferred an inherent cardioprotection, and 2) a pretreatment dose of adenosine before ischemia would provide additional protection independent of hemodynamic effects. METHODS AND RESULTS Thirty-six anesthetized New Zealand White rabbits underwent 30 minutes of regional ischemia produced by coronary occlusion followed by 2 hours of reperfusion. The adenosine group (ADO, n = 9) received a 5-minute pretreatment… CONTINUE READING
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