Myocardial protective effect of octylguanidine against the damage induced by ischemia reperfusion in rat heart

@article{Parra2005MyocardialPE,
  title={Myocardial protective effect of octylguanidine against the damage induced by ischemia reperfusion in rat heart},
  author={El{\'i}as Parra and David Cruz and Gerardo Garc{\'i}a and Cecilia Zazueta and Francisco Correa and Noem{\'i} Garc{\'i}a and Edmundo Ch{\'a}vez},
  journal={Molecular and Cellular Biochemistry},
  year={2005},
  volume={269},
  pages={19-26}
}
This study shows that the hydrophobic cation octylguanidine protects against myocardial damage induced by ischemia-reperfusion. The protective effect of the amine was analyzed after 5 min of coronary occlusion followed by 5 min reperfusion in rat hearts. ECG tracings from rats treated with an i.v. injection of 5 mg/kg of octylguanidine showed a total absence of post-reperfusion arrhythmias, conversely to what was observed in untreated rats. The histological images showed that myocardium fibers… Expand
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