Myocardial protection by selective poly(ADP-ribose) polymerase inhibitors.

  title={Myocardial protection by selective poly(ADP-ribose) polymerase inhibitors.},
  author={Krisztina Kov{\'a}cs and Ambrus T{\'o}th and P{\'e}ter Deres and T{\'a}m{\'a}s K{\'a}l{\'a}i and K{\'a}lm{\'a}n Hideg and Bal{\'a}zs Sumegi},
  journal={Experimental and clinical cardiology},
  volume={9 1},
During ischemia-reperfusion, reactive oxygen species are generated along the mitochondrial respiratory chain and induce lipid peroxidation, protein oxidation and DNA damage. Single-strand DNA breaks are the most potent activators of poly(ADP-ribose) polymerase (PARP); prolonged action of PARP culminates in intracellular oxidized nicotinamide adenine dinucleotide (NAD(+)) and ATP depletion. The integrity of cellular components and the myocardial energy metabolism can be preserved by using PARP… CONTINUE READING
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