Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling.

@article{Jonassen2001MyocardialPB,
  title={Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling.},
  author={Anne Kristin Jonassen and Michael N. Sack and Ole D. Mj\os and Derek M Yellon},
  journal={Circulation research},
  year={2001},
  volume={89 12},
  pages={1191-8}
}
The "metabolic cocktail" comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this protection and acts via Akt prosurvival signaling. This hypothesis was studied in isolated perfused rat hearts (measuring infarct size to area of risk [%]) subjected to 35 minutes regional myocardial ischemia and 2 hours reperfusion. Insulin administered at the onset of reperfusion attenuated… CONTINUE READING
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